A more thorough explanation:

Definition: To separate or keep away a person or thing, or to destroy affection, trust, and loyalty.

Example 1: After the argument, John and his best friend became estranged and stopped talking to each other.

Example 2: The company's unethical practices estranged many of its loyal customers.

These examples illustrate how estrange means to create a distance or separation between people or things. In example 1, the argument caused a rift between John and his friend, leading to estrangement. In example 2, the company's actions caused customers to lose trust and loyalty, resulting in estrangement.